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KMID : 0361120020160010038
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Korean Journal of Transplantation
2002 Volume.16 No. 1 p.38 ~ p.46
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Association of Polymorphisms of the TNF-α and TGF-β1 Genes with Renal Allograft Dysfunction
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박지영*,∥/Ji Young Park*,∥
박명희*,§/박혜진*/하종원†,§/김상준†,§/안규리‡,§/Myoung Hee Park*,§/Hye Jin Park*/Jong Won Ha†,§/Sang Joon Kim†,§/Cu Rie Ahn‡,§
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Abstract
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Purpose: Tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β1 have been shown to play important roles in allograft rejection of various organs. This study was performed to evaluate the association of TNF-α and TGF-β1
genes
and renal allograft dysfunction.
Methods: Five TNF-α (-1,031 T/C, -863 C/A, -857 C/T, -308 G/A, -238 G/A) and two TGF-β1 (codon 10 T/C, codon 25 G/C) single nucleotide polymorphism (SNP) sites were studied using PCR-SSCP and PCR-RFLP methods in 100 controls and 165
patients
underwent renal transplantation. For the TGF-β1 gene, we also studied the polymorphism of donors.
Results: The allele frequencies of each SNP sites in controls were not different from those of patients. The phenotype frequency of TNF-α high producer type, -308 A was significantly higher in the patients with recurrent acute rejection
episodes
(REs) compared with patients with no or one RE (38.5% vs. 9.2%, P=0.007). The frequency of TGF-β1 low producer genotype, codon 10 CC was also significantly higher in the patients with recurrent REs (53.8% vs. 22.4%, P=0.029). Analysis of
chronic
renal
allograft dysfunction (CRAD) revealed that the TGF-β1 high producer type, codon 10 T allele in donors was associated with CRAD (66.7% vs. 48.2%, P=0.043). This association was significant only among patients with recurrent REs. Occurrence of
CRAD
was
not influenced by TGF-β1 polymorphisms in the patients.
Conclusion: These results would be useful for predicting high risk group for acute rejection or CRAD in renal transplantation and might be useful for implying individualized immunosuppressive therapy.
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KEYWORD
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